Top of pageClinical presentationsClinical presentations in adultsBumping into things: the Pulfrich phenomenon Delayed retinal processing or delayed conduction from one eye with respect to the other leads to a temporal mismatch of the incoming visual information, which leads to inaccuracy of perception of the position of moving targets in three dimensional space.23 This results in an inappropriate compensatory movement of the limbs or body (Figure 2). While this can be considered a peripheral disorder, it is the central interpretation of where things are in visual space that is disturbed and causes problems. The left eye (blue) ‘sees’ the approaching target ahead of the affected left eye (red).
COS 1 cells were transfected with Myc tagged dynamin 2 and different GFP tagged BIN1 constructs: wild type and mutated full length BIN1 iso8 and wild type BAR (aa 1 282, lacking the SH3 domain at the C terminus). Dynamin 2 localization was revealed with an anti Myc antibody. Dynamin 2 recruitment to the membrane tubules induced by BIN1 iso8 was dependent on a wild type SH3 domain, as both deletion of the SH3 domain or the last 19 aminoacids (K575X mutant) abrogated the recruitment.
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